Jonathan W. Martin

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University of Texas at Dallas, Computational biologist

Hello! I’m a PhD researcher, interested in how complex biological systems adapt to their environment.

I’m fascinated by the methods which living organisms use to store information in functional systems; things like proteins, protein networks, and higher order structures like cellular networks. Questions like:

  • What is the “functional” capacity of a polymer like a protein?
  • How efficiently can biological systems capture information about the environment? (maximum predictive power of a future environmental state, lowest amount of information; how close is evolution to this?)
  • How quickly can organisms adapt to a changing environment? On what timescales should we expect adaptation given some environmental change?

Also interested in designing information theoretic approaches to enzyme design/characterization because they are powerful for situations biologists commonly live in: lack of prior experimental validation and low resources for testing (see my work in this eLife paper).

And… I’m an avid birdwatcher! I love birds, and also photographing them!

publications

  1. lgl.png
    Latent generative landscapes as maps of functional diversity in protein sequence space
    Cheyenne Ziegler , Jonathan Martin, Claude Sinner , and 1 more author
    Nat. Commun., Apr 2023
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    Lipid discovery enabled by sequence statistics and machine learning
    Priya M. Christensen , Jonathan Martin, Aparna Uppuluri , and 5 more authors
    eLife, Feb 2024
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    Machine learning in biological physics: From biomolecular prediction to design
    Jonathan Martin, Marcos Lequerica Mateos , José N. Onuchic , and 2 more authors
    Proc. Natl. Acad. Sci. U.S.A., Jul 2024
  4. malatedehydro.jpg
    Thermal Adaptation of Cytosolic Malate Dehydrogenase Revealed by Deep Learning and Coevolutionary Analysis
    Divyanshu Shukla , Jonathan Martin, Faruck Morcos , and 1 more author
    J. Chem. Theory Comput., Mar 2025